Dialog Box

PPCG

Pan Prostate Cancer Group

Lead Institution

Institute of Cancer Research

Country

United Kingdom

Program Description

The Pan Prostate Cancer Group (PPCG) consists of groups worldwide (UK, Germany, USA, Canada, France, Australia, Finland) that have whole genome, transcriptome and epigenome data from over 2000 prostate tumours linked to rich clinical outcome information. The consortium’s data represent both localised and metastatic prostate cancers that also address differences in ethnicity, DNA repair gene carrier status, common germline variant polygenic risk status and variable age groups. Importantly, long-term outcome (median >5 yrs) is also available on many of these patients and so clinic-genomic correlates can be made to determine novel factors that predict biochemical failure-free, and metastasis-free, survival. The major objective of the consortium is to identify markers that will allow us to distinguish between aggressive and non-aggressive prostate cancer at the time of diagnosis or metastasis. This represents a fundamental problem for around half of the 500,000 men diagnosed with prostate cancer in Europe and North America each year. Additionally, the data should provide insights into disease mechanism and identify possible new treatment paradigms. 

Clinical questions that the consortium will address are:

  1. What is the best multimodal biomarker of aggressive disease?
  2. What biomarkers determine response to radiotherapy versus surgery? 
  3. Which germline variants, including DNA repair gene mutations and common genetic variation, predict for aggressive versus indolent disease and what are germline-somatic associations in this regard?
  4. What determines first echelon oligometastasis and successful treatment response? 
  5. What biomarkers are candidates for predictors of response to ADT or drug treatments?

Program Team

Rosalind Eeles

Lead Investigator


Name

Role

Institution, location

Professor Colin Cooper

Co-PI, Lead Investigator

University of East Anglia

Professor Rosalind Eeles

Co-PI, Lead Investigator

The Institute of Cancer Research

Professor Rob Bristow

Clinical and functional assessment

University of Manchester

Professor Benedikt Brors

PI, Informatics

DKFZ

Dr Geraldine Cancel-Tassin

Co-Principal Investigator

CeRePP

Professor Olivier Cussenot

Principal Investigator, Clinical

CeRePP

Professor G. Steven Bova,

PI, clinical, pathology

Tampere University, Finland

Matti Nykter

Computational Biology

Tampere University, Finland

Professor Karina Dalsgaard Sorensen

PI, Aarhus study

Aarhus University, Denmark

Mr Vincent Gnanapragasam

Urologist

University of Cambridge

Vanessa Hayes

PI, Sequencing

Garvan Institute of Medical Research, Australia

Professor Christopher Hovens

PI, Sequencing

University of Melbourne, Australia

Thomas Keane

PI, Informatics

EMBL

Dr Adam Kibel

PI, Clinical

The Brigham & Womens Hospital

Dr Jan Korbel

PI, Informatics

EMBL

Dr Massimo Loda

PI, Pathology

Weill Cornell Medicine

Juri Reimand

PI, Informatics

Ontario Institute for Cancer Research, Canada

Michael Fraser

PI, Translational Genomics

Princess Margaret Cancer Centre / University of Toronto, Canada

Chris Sander

Coordination. Informatics: Linking to TCGA data and pathway analysis.

Dana-Farber Cancer Institute, Boston, MA

Professor Thorsten Schlomm

Clinical Working Group

Charité  - Universitäsmedizin Berlin, Germany

Theo Van Der Kwast

Pathologist

University Health Network (UHN), Toronto, Canada

Dr David Wedge

Group Leader

University of Oxford (UK)

Joachim Weischenfeldt

Informatics

Biotech Research & Innovation Centre (BRIC)

Francesco Favero

Informatics

Finsen laboratory, Rigshospitalet

Etsehiwot Girum Girma

Informatics

University of Copenhagen

Alain Viari

Informatics

Fondation Synergie, Lyon (France)

Laurie Tonon

Informatics

Fondation Synergie, Lyon (France)

Gaelle Fromont

Pathology

CHU Tours, Tours (France)

Bogdan Pasaniuc

Computational Biology

UCLA, USA



Funding Organisations

Academy of Finland

Helsinki, Finland

aka.fi 

Cancer Society of Finland

Helsinki, Finland

cancersociety.fi 


Sigrid Juselius Foundation

Helsinki, Finland

sigridjuselius.fi 


Business Finland

Helsinki, Finland

businessfinland.fi 

Independent Research Fund Denmark

Copenhagen, Denmark

dff.dk/en 

Danish Cancer Society

Copenhagen, Denmark

cancer.dk 

University of Melbourne

Melbourne, Australia

medicine.unimelb.edu.au 

Ontario Institute for Cancer Research

Toronto, Canada

oicr.on.ca 

Prostate Cancer Canada

Toronto, Canada

prostatecancer.ca 

Dana-Farber Cancer Institute

Boston, MA

DFCI.org 


BMBF

Berlin, Germany

bmbf.de 

Li Ka Shing foundation

Hong Kong, PRC

lksf.org 

National Institutes of Health

Bethesda, USA

nih.gov 

National Institute for Health Research

London, UK

nihr.ac.uk 


Rigshospitalet’s Research Foundation

Copenhagen, Denmark

forskningspuljer-rh.dk 


UCLA

LA, USA

ucla.edu 


Further Information

Program Website

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