Dialog Box

HKBM

Genomics of Brian Metastasis Project


Lead Institution

Hong Kong University of Science and Technology and China Pharmaceutical University

The Chinese University of Hong Kong, Hong Kong

Country

Hong Kong, China

Project Description

The proposed project aims to study the genomics of brain metastases from lung and colorectal cancers from the perspective of clinical applications. Brain metastasis is one of the most severe complications and often a cause of death of cancers. Among the five types of cancers most prone to brain metastasis, lung and colorectal cancers have the highest incidences in China. In particular, the incidence of lung cancer in Hong Kong is the highest in the world. We propose to carry out a longitudinal study on non-small cell lung cancers and colorectal adenocarcinomas for brain metastasis genomics.

Project Goals and Expected Outcomes

To work out the genomic abnormalities of primary lung and colorectal cancers prone to develop brain metastasis.

What gaps in existing knowledge will be addressed by the study?

Lung cancer and colorectal cancer patients at risk of developing brain metastasis.


Project Team

Prof. Hannah Hong XUE, PhD and Prof. Wai Sang Poon, MD

Lead Investigators

Hong Kong University of Science and Technology, and China Pharmaceutical University

The Chinese University of Hong Kong


Name

Role

Institution, location

Mao De Lai

Pathological analysis

China Pharmaceutical University

Randy Poon

Cancer biology analysis

Hong Kong University of Science and Technology

Ning Li

Proteomics analysis

Hong Kong University of Science and Technology

Chun Liang

Cancer biology analysis

Hong Kong University of Science and Technology

Can Yang

Bioinformatics analysis 

Hong Kong University of Science and Technology

Ting-Fung Chan

Transcriptomics and Bioinformatics analysis

The Chinese University of Hong Kong

Lin Xu

Lung cancer clinical

Jiangsu Provincial Hospital of Oncology

Rong Yi

Lung cancer samples and clincial information

Jiangsu Provincial Hospital of Oncology

Zhiqian Hu

Colorectal cancer samples and clinical information

Shanghai Changzheng Hospital

Xingxin Li

Colorectal cancer samples and clinical information

Shanghai Changzheng Hospital

Zhong Ping Chen

Brain metastatic cancer samples and clinical information

Sun Yat-sen University Cancer Center

Kui Wu

Genomics and transcriptomics analyses

BGI Research Institute

Xiao-sheng Wang

Bioinformatics analysis

China Pharmaceutical University



Funding Organisations

Innovation and Technology Commission, Hong Kong Special Administrative Region Government

Hong Kong, China

itc.gov.hk 


Ministry of Science and Technology, China

Beijing, China

most.gov.cn 


Further Information

PROJECT WEBSITE 


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