Genomics of Brain Metastasis Project
Lead Institution
Hong Kong University of Science and Technology and China Pharmaceutical University
The Chinese University of Hong Kong, Hong Kong
Program Description
The proposed project aims to study the genomics of brain metastases from lung and colorectal cancers from the perspective of clinical applications. Brain metastasis is one of the most severe complications and often a cause of death of cancers. Among the five types of cancers most prone to brain metastasis, lung and colorectal cancers have the highest incidences in China. In particular, the incidence of lung cancer in Hong Kong is the highest in the world. We propose to carry out a longitudinal study on non-small cell lung cancers and colorectal adenocarcinomas for brain metastasis genomics.
Program Goals and Expected Outcomes
To work out the genomic abnormalities of primary lung and colorectal cancers prone to develop brain metastasis.
What gaps in existing knowledge will be addressed by the study?
Lung cancer and colorectal cancer patients at risk of developing brain metastasis.
Program Team
Prof. Hannah Hong XUE, PhD and Prof. Wai Sang Poon, MD
Lead Investigators
Hong Kong University of Science and Technology, and China Pharmaceutical University
The Chinese University of Hong Kong
China Pharmaceutical University
Hong Kong University of Science and Technology
Hong Kong University of Science and Technology
Hong Kong University of Science and Technology
Hong Kong University of Science and Technology
Transcriptomics and Bioinformatics analysis
The Chinese University of Hong Kong
Jiangsu Provincial Hospital of Oncology
Lung cancer samples and clincial information
Jiangsu Provincial Hospital of Oncology
Colorectal cancer samples and clinical information
Shanghai Changzheng Hospital
Colorectal cancer samples and clinical information
Shanghai Changzheng Hospital
Brain metastatic cancer samples and clinical information
Sun Yat-sen University Cancer Center
Genomics and transcriptomics analyses
China Pharmaceutical University
Funding Organisations
Innovation and Technology Commission, Hong Kong Special Administrative Region Government
Hong Kong, China
itc.gov.hk
Ministry of Science and Technology, China
Beijing, China
most.gov.cn
Further Information
PROGRAM WEBSITE