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WC-CPMP

Weill Cornell Cancer Precision Medicine Program

Lead Institution

Weill Cornell Medical College, Englander Institute for Precision Medicine

Country

USA

Project Description

At the Englander Institute for Precision Medicine, advanced cancer patients will be prospectively consented and enrolled on an existing precision medicine clinical trial, which includes a new metastatic biopsy, whole exome sequencing (WES) of tumour/normal DNA, whole transcriptome profiling (WTS) of tumour by RNA Sequencing, and the development of preclinical models from metastatic tumour biopsies. Our project is pan-cancer with all major tumour types represented as well as less frequent tumour types including paediatric tumours.

Project Goals and Expected Outcomes

Our project is pan-cancer with all major cancer types represented as well as less frequent tumour types including paediatric tumours. By combining genomic data with circulating tumour analysis, transcriptomic data and organoid model development we aim to utilize a multi- faceted approach to better understand the molecular roots of cancer.

What gaps in existing knowledge will be addressed by the study?

All too often, cancer patients become resistant to therapies for reasons we do not yet understand. We aim to use our characterization data paired with our organoid models to evaluate drug resistance and use the results to drive new discoveries in overcome this unmet need.


Project Team

Olivier Elemento, PhD.

Lead Investigator

Weill Cornell Medical College


Name

Role

Institution, location

Cora Sternberg

Director of Clinical and Translational Research

Englander Institute for Precision Medicine, Weill Cornell Medicine, USA

Andrea Sboner

Director of Informatics and Computational Biology

Englander Institute for Precision Medicine, Weill Cornell Medicine, USA

Wei Song

Director of Clinical Pathology

Englander Institute for Precision Medicine, Weill Cornell Medicine, USA



Funding Organisations

National Cancer Institute

Bethesda, USA

cancer.gov 

National Institutes of Health

Bethesda, USA

nih.gov 

Qatar National Research Fund (QNRF)

Doha, Qatar

qnrf.org 

Leukemia & Lymphoma Society

Bethesda, USA

lls.org 

National Heart, Lung, & Blood Institut

Bethesda, USA

nhlbi.nih.gov 


Further Information

Project Website

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