Key Objectives:
The Pathology Working Group will capture the pathology related to the genomic data of ARGO patients. In addition to comprehensive genomic and clinical data sets, many ARGO programs will routinely capture digital pathology images of each participant sample acquired as part of the study. Both imaging and genomic data are extremely high-dimensional; molecular profiling data generate deep characterizations of the genetic, transcriptional, and proteomic events in tumours, while pathology images capture the tumour histology, growth pattern, and interactions with the surrounding microenvironment. Using this wealth of data collectively would provide a platform to explore the relationship between patient genomic profiles and pathological and morphological phenotypes, which is essential for understanding the biological mechanisms underpinning cancer development and for exploring how cancers change over time and with treatment. In more common cancers, such as breast and lung, this area is well-developed, but in less common cancers there is no classification or taxonomy after treatment, which is a very important area. There is an opportunity within ARGO using the molecular data to find themes and explore insights that may be missed if we do not collate the pathology at a detailed level.
Working Group Leader(s) Name Institution and contact:
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Mark Rubin, MD
Director DBMR, University of Bern, Switzerland
Mark Rubin is a physician-scientist with board training in surgical pathology and expertise in molecular and genitourinary pathology with a focus on prostate cancer.
Over the past 8 years, he has been dedicated to the development of Precision Medicine approaches to advanced cancer care. In 2013, Mark Rubin founded the Englander Institute for Precision Medicine (PM) at Weill Cornell Medicine and New York-Presbyterian Hospital. The program established a clinical protocol for patients with advanced cancer who failed standard of care therapy. In 2017, Mark Rubin moved full time to the University of Bern to found the Bern Center for Precision Medicine for the Canton of Bern. This activity has required also establishing a node for the pan-Swiss national PM effort. He has taken the lead for organizing the cancer genomics effort for this National program and chair the Federated Genomics Committee responsible for the development of recommendations to the Swiss Government for future scientific investments in genomics research.
Working Group Contact:
Email - secretariat@icgc-argo.org
Current Membership List:
Garvan Institute of Medical Research
University of Verona, Italian Ministry of Education, University and Research
International Agency for Research on Cancer (IARC)
Vancouver General Hospital, BC Cancer Michael Smith Genome Sciences Centre
Englander Institute- Weill Cornell Medicine
Verona University and Hospital Trust
The Sixth Affiliated Hostpital of Sun Yat-sen University
Peking University Cancer Hospital
Cambridge University Hospital NHS Trust
Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois
University Health Network
Seoul National University Hospital
University and University Hospital Zurich